2011年度浙江省科技进步奖推荐公示

经省中医药管理局推荐，以下课题拟参加2011年度的浙江省科技进步奖评审，特此公示 ：

课题名称：黄芩甙对急性坏死性胰腺炎炎症介质及多脏器细胞凋亡的影响
主要完成单位：杭州市第一人民医院
主要完成人员的项目分工：张喜平（课题设计、实施、管理、总结）、封光华（课题实施）、王克义（血清检测）、徐如君（病理检测）、严伟（黄芩甙/苷注射液制备）、程琪辉（资料整理）   
获得的知识产权证明：“一种黄芩苷液配制方法”获得国家发明专利，专利授权号ZL200310122673.6

 发表的10篇代表性论文目录：
(1).Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis.Pancreas. 2009 ;38(7):732-8.  
(2).Effects of Baicalin and Octreotide on inflammatory mediators and pancreatic acinar cell apoptosis in rats with severe acute pancreatitis.Journal of research in medical sciences(JRMS).2009,14(1):19-27 
(3). Effect of baicalin and octreotide on the expression levels of P-selectin protein in multiple organs of rats with severe acute pancreatitis. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 2009,24(11):1753-1762  
(4). Progress of study on the relationship between mediators of inflammation and apoptosis in acute pancreatitis.Dig Dis SCI. 2007 May;52(5):1199-205  
(5).Experimental study of therapeutic efficacy of Baicalin in rats with severe acute pancreatitis.World J Gastroenterol. 2007;13(5):717-24.  
(6).Pathological changes in multiple organs of rats with severe acute pancreatitis treated by baicalin and octreotide.Hepatobiliary Pancreat Dis Int. 2009;8(1):85-92. 
(7).Influence of Baicalin and Octreotide on NF-kappaB and P-Selectin Expression in Liver and Kidney of Rats with Severe Acute Pancreatitis.Inflammation. 2009;32(1):1-11. 
(8). Protective Effects of Baicalin and Octreotide on Multiple Organ Injury in Severe Acute Pancreatitis.Dig Dis Sci. 2008 Feb;53(2):581-591. 
(9).The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP.Mediators Inflamm. 2007;2007:19469.  
(10).Effects of Baicalin and Octreotide on the Serum TNF-α Level and Apoptosis in Multiple Organs of Rats with Severe Acute Pancreatitis. Inflammation, 2009,32(3):191-201   

取得的社会经济效益：

(1)本课题有望为ANP的治疗提供一种价廉、效好的新药；
(2)已经建立起了900多只ANP大鼠的多脏器组织芯片库，将为国内外其他学者的相关研究提供方便；
(3)课题负责人提出的多脏器病理评分标准陆续发表在SCI期刊，并已有学者采用，有望得到进一步推广和应用；
(4)截止2010年1月课题负责人作为第一作者或第二作者（兼通讯作者）在国内外已经发表与课题相关的论文49篇，其中在一级期刊发表19篇，二级期刊发表14篇。总共有16篇论文被SCI收录，其中9篇共被他引28次；总共有34篇中文论文被他引437次。